Beilstein J. Org. Chem.2015,11, 249–264, doi:10.3762/bjoc.11.28
natural metabolites available from plants, phenolic compounds play a particularly important role in human health as they occur in significant amounts in many fruits, vegetables and medicinal plants. In this review naturalphenoliccompounds of plant origin with significant anti-angiogenic properties are
described.
Keywords: angiogenesis; naturalphenoliccompounds; structure–activity relationship; synthesis; Introduction
The term angiogenesis is commonly used to describe the biological process of blood vessel growth. Nevertheless, it should be more precisely defined as the formation of new blood vessels
biological and pharmacological aspects of anti-angiogenic compounds, including natural compounds containing a phenolic substructure [12][13][14]. To complement this previously discussed pharmacological point of view, this review focuses on recent reports of anti-angiogenic, natural, phenoliccompounds
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Graphical Abstract
Figure 1:
Structure of 4-hydroxybenzyl alcohol (HBA, 1).
Beilstein J. Org. Chem.2012,8, 1884–1889, doi:10.3762/bjoc.8.217
diseases. The role of free radicals in ageing, in cancer, and in cardiovascular, neurodegenerative and other diseases is more and more widely accepted [21][22]. Antioxidants are attracting increasing scientific and clinical attention.
Naturalphenoliccompounds (flavonoids, lignans, phenolic acids
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Graphical Abstract
Figure 1:
Structures of selaginellins from S. tamariscina.